Hot-Melt Extrusion : Pharmaceutical Applications by Dennis Douroumis
--------------------------------------------------------------- Author: Dennis Douroumis Page Count: 382 pages Published Date: 26 Jun 2012 Publisher: John Wiley and Sons Ltd Publication Country: Hoboken, United States Language: English Format: eBook ISBN: 9780470711187 File Name: Hot-Melt.Extrusion.Pharmaceutical.Applications.pdf Download Link: Hot-Melt Extrusion Pharmaceutical Applications --------------------------------------------------------------- Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: * principles and die design of single screw extrusion * twin screw extrusion techniques and practices in the laboratory and on production scale * HME developments for the pharmaceutical industry * solubility parameters for prediction of drug/polymer miscibility in HME formulations * the influence of plasticizers in HME * applications of polymethacrylate polymers in HME * HME of ethylcellulose, hypromellose, and polyethylene oxide * bioadhesion properties of polymeric films produced by HME * taste masking using HME * clinical studies, bioavailability and pharmacokinetics of HME products * injection moulding and HME processing for pharmaceutical materials * laminar dispersive & distributive mixing with dissolution and applications to HME * technological considerations related to scale-up of HME processes * devices and implant systems by HME * an FDA perspective on HME product and process understanding * improved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science. This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here. Read online Hot-Melt Extrusion : Pharmaceutical Applications Buy Hot-Melt Extrusion : Pharmaceutical Applications Download and read Hot-Melt Extrusion : Pharmaceutical Applications ebook, pdf, djvu, epub, mobi, fb2, zip, rar, torrent Download to iPad/iPhone/iOS, B&N nook Hot-Melt Extrusion : Pharmaceutical Applications Related entries: Plumbing Estimates and Contracts downloadPDF, EPUB, MOBILiving with a Wild God : A Nonbeliever's Search for the Truth about Everything download pdf The Road to Ratchet Creek download PDF, EPUB, Kindle Important Role of Remedial Plants in Medicine download torrent need for speed most wanted 2012 crack skidrow chomikuj Zur Geschichte Der Pflege Der Naturwissenschaften in M Hren Und Schlesien : Insbesondere Der Naturkunde Dieser L Nder, Mit R Cksicht Auf B Hmen Und Oesterreich epub Sharknife: Stage First Volume 1 download PDF, EPUB, Kindle Children's Booklist downloadPDF, EPUB, MOBI
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